Pharmacogenomics of intracellular methotrexate polyglutamates in patients’ leukemia cells in vivo

BACKGROUND: Interpatient differences in the accumulation of methotrexate’s active polyglutamylated metabolites (MTXPGs) in leukemia cells influence its antileukemic effects. METHODS: To identify genomic and epigenomic and patient variables determining the intracellular accumulation of MTXPGs, we mea...

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Vydáno v:J Clin Invest
Hlavní autoři: Lopez-Lopez, Elixabet, Autry, Robert J., Smith, Colton, Yang, Wenjian, Paugh, Steven W., Panetta, John C., Crews, Kristine R., Bonten, Erik J., Smart, Brandon, Pei, Deqing, McCorkle, J. Robert, Diouf, Barthelemy, Roberts, Kathryn G., Shi, Lei, Pounds, Stanley, Cheng, Cheng, Mullighan, Charles G., Pui, Ching-Hon, Relling, Mary V., Evans, William E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685728/
https://ncbi.nlm.nih.gov/pubmed/33164984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140797
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