Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.

Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is commonly given in high doses. However, the rationale for high-dose MTX (HDMTX) has been challenged recently. To determine whether higher MTX polyglutamate (MTXPG) concentr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Masson, E, Relling, M V, Synold, T W, Liu, Q, Schuetz, J D, Sandlund, J T, Pui, C H, Evans, W E
Format: Artigo
Langue:Inglês
Publié: 1996
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC507064/
https://ncbi.nlm.nih.gov/pubmed/8550853
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