Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.

Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is commonly given in high doses. However, the rationale for high-dose MTX (HDMTX) has been challenged recently. To determine whether higher MTX polyglutamate (MTXPG) concentr...

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發表在:	J Clin Invest
Principais autores:	Masson, E, Relling, M V, Synold, T W, Liu, Q, Schuetz, J D, Sandlund, J T, Pui, C H, Evans, W E
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical Investigation 1996
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507064/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8550853/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118409
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