Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate.

Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphoblastic leukemia (ALL) and is commonly given in high doses. However, the rationale for high-dose MTX (HDMTX) has been challenged recently. To determine whether higher MTX polyglutamate (MTXPG) concentr...

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Detaylı Bibliyografya
Asıl Yazarlar: Masson, E, Relling, M V, Synold, T W, Liu, Q, Schuetz, J D, Sandlund, J T, Pui, C H, Evans, W E
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 1996
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC507064/
https://ncbi.nlm.nih.gov/pubmed/8550853
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