Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic activity of phosphoribosylaminoimidazolecarboxamide (AICAR) transformylase purified from MCF-7 human breast cancer cells. In the present work, MTX (4-amino-10-methylpteroy...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Allegra, C J, Drake, J C, Jolivet, J, Chabner, B A
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1985
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3860829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.15.4881
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