Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic activity of phosphoribosylaminoimidazolecarboxamide (AICAR) transformylase purified from MCF-7 human breast cancer cells. In the present work, MTX (4-amino-10-methylpteroy...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Allegra, C J, Drake, J C, Jolivet, J, Chabner, B A
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1985
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3860829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.15.4881
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