Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic activity of phosphoribosylaminoimidazolecarboxamide (AICAR) transformylase purified from MCF-7 human breast cancer cells. In the present work, MTX (4-amino-10-methylpteroy...

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Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Allegra, C J, Drake, J C, Jolivet, J, Chabner, B A
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 1985
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3860829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.15.4881
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