Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.

We have characterized the determinants of methotrexate (MTX) responsiveness in eight patient-derived cell lines of small-cell lung cancer (SCLC). Clonogenic survival was correlated with factors known to affect sensitivity to drug. NCI-H209 and NCI-H128 were most drug sensitive, with drug concentrati...

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Publié dans:	J Clin Invest
Auteurs principaux:	Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, Chabner, B A
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Clinical Investigation 1985
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC424067/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2414316/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112106
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