Determinants of the sensitivity of human small-cell lung cancer cell lines to methotrexate.

We have characterized the determinants of methotrexate (MTX) responsiveness in eight patient-derived cell lines of small-cell lung cancer (SCLC). Clonogenic survival was correlated with factors known to affect sensitivity to drug. NCI-H209 and NCI-H128 were most drug sensitive, with drug concentrati...

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Hauptverfasser: Curt, G A, Jolivet, J, Carney, D N, Bailey, B D, Drake, J C, Clendeninn, N J, Chabner, B A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1985
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC424067/
https://ncbi.nlm.nih.gov/pubmed/2414316
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