Methotrexate polyglutamate synthesis by cultured human breast cancer cells.
We studied the conversion of methotrexate to poly-gamma-glutamyl derivatives by cultured human breast cancer cells. After incubation with 2 micro M [3',5',9-3H]methotrexate, MCF-7 cells were washed free of extracellular drug and were boiled to lyse cells and to release drug bound to dihydrofolate re...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1980
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349517/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6156458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.5.2919 |
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