Methotrexate polyglutamate synthesis by cultured human breast cancer cells.

We studied the conversion of methotrexate to poly-gamma-glutamyl derivatives by cultured human breast cancer cells. After incubation with 2 micro M [3',5',9-3H]methotrexate, MCF-7 cells were washed free of extracellular drug and were boiled to lyse cells and to release drug bound to dihydrofolate re...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Schilsky, R L, Bailey, B D, Chabner, B A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1980
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC349517/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6156458/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.77.5.2919
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