Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates.

We report the enhanced inhibitory potency of methotrexate (MTX) polyglutamates and dihydrofolate pentaglutamate on the catalytic activity of phosphoribosylaminoimidazolecarboxamide (AICAR) transformylase purified from MCF-7 human breast cancer cells. In the present work, MTX (4-amino-10-methylpteroy...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Allegra, C J, Drake, J C, Jolivet, J, Chabner, B A
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1985
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC390461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3860829/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.15.4881
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