Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with A...

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Detalhes bibliográficos
Main Authors: Ramsey, Laura B., Bruun, Gitte H., Yang, Wenjian, Treviño, Lisa R., Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L., Giacomini, Kathleen M., Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S., Corydon, Thomas J., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246196/
https://ncbi.nlm.nih.gov/pubmed/22147369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129668.111
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