Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with A...

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Bibliografiske detaljer
Main Authors: Ramsey, Laura B., Bruun, Gitte H., Yang, Wenjian, Treviño, Lisa R., Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L., Giacomini, Kathleen M., Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S., Corydon, Thomas J., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246196/
https://ncbi.nlm.nih.gov/pubmed/22147369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129668.111
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