Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with A...

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Autores principales: Ramsey, Laura B., Bruun, Gitte H., Yang, Wenjian, Treviño, Lisa R., Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L., Giacomini, Kathleen M., Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S., Corydon, Thomas J., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2012
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246196/
https://ncbi.nlm.nih.gov/pubmed/22147369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129668.111
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