Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with A...

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Détails bibliographiques
Auteurs principaux: Ramsey, Laura B., Bruun, Gitte H., Yang, Wenjian, Treviño, Lisa R., Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L., Giacomini, Kathleen M., Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S., Corydon, Thomas J., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2012
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246196/
https://ncbi.nlm.nih.gov/pubmed/22147369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129668.111
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