Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with A...

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Hauptverfasser: Ramsey, Laura B., Bruun, Gitte H., Yang, Wenjian, Treviño, Lisa R., Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L., Giacomini, Kathleen M., Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S., Corydon, Thomas J., Pui, Ching-Hon, Evans, William E., Relling, Mary V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2012
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246196/
https://ncbi.nlm.nih.gov/pubmed/22147369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129668.111
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