Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

The mTORC1 pathway regulates cell growth and proliferation by properly coupling critical processes such as gene expression, protein translation, and metabolism to the availability of growth factors and hormones, nutrients, cellular energetics, oxygen status, and cell stress. Although multiple cytopl...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: He, Long, Fei, Dennis Liang, Nagiec, Michal J., Mutvei, Anders P., Lamprakis, Andreas, Kim, Bo Yeon, Blenis, John
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765302/
https://ncbi.nlm.nih.gov/pubmed/31492813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902397116
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