Regulation of GSK3 cellular location by FRAT modulates mTORC1-dependent cell growth and sensitivity to rapamycin

The mTORC1 pathway regulates cell growth and proliferation by properly coupling critical processes such as gene expression, protein translation, and metabolism to the availability of growth factors and hormones, nutrients, cellular energetics, oxygen status, and cell stress. Although multiple cytopl...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: He, Long, Fei, Dennis Liang, Nagiec, Michal J., Mutvei, Anders P., Lamprakis, Andreas, Kim, Bo Yeon, Blenis, John
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6765302/
https://ncbi.nlm.nih.gov/pubmed/31492813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902397116
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