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Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability
The kinase mTOR complex 1 (mTORC1) promotes cellular growth and is frequently dysregulated in cancers. In response to nutrients, mTORC1 is activated on lysosomes by Rag and Rheb guanosine triphosphatases (GTPases) and drives biosynthetic processes. How limitations in nutrients suppress mTORC1 activi...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7078236/ https://ncbi.nlm.nih.gov/pubmed/32184389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15156-5 |
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