Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

The kinase mTOR complex 1 (mTORC1) promotes cellular growth and is frequently dysregulated in cancers. In response to nutrients, mTORC1 is activated on lysosomes by Rag and Rheb guanosine triphosphatases (GTPases) and drives biosynthetic processes. How limitations in nutrients suppress mTORC1 activi...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Mutvei, Anders P., Nagiec, Michal J., Hamann, Jens C., Kim, Sang Gyun, Vincent, C. Theresa, Blenis, John
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7078236/
https://ncbi.nlm.nih.gov/pubmed/32184389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15156-5
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