Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways

Cadmium (Cd), a toxic environmental contaminant, contributes to neurodegeneration. Rapamycin, a macrocyclic lactone, has shown preventive effect on Cd-induced neuronal cell death. However, the underlying mechanism is not fully understood. Here, we show that rapamycin prevented Cd-induced apoptotic c...

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Pubblicato in:Neuropharmacology
Autori principali: Xu, Chong, Liu, Chunxiao, Liu, Lei, Zhang, Ruijie, Zhang, Hai, Chen, Sujuan, Luo, Yan, Chen, Long, Huang, Shile
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4537379/
https://ncbi.nlm.nih.gov/pubmed/26002629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2015.05.008
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