Rapamycin attenuates BAFF-extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B-lymphoid cells

B cell activating factor from the TNF family (BAFF) stimulates B-cell proliferation and survival, but excessive BAFF promotes the development of aggressive B cells leading to malignant and autoimmune diseases. Recently, we have reported that rapamycin, a macrocyclic lactone, attenuates human soluble...

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Vydáno v:J Cell Physiol
Hlavní autoři: Zeng, Qingyu, Qin, Shanshan, Zhang, Hai, Liu, Beibei, Qin, Jiamin, Wang, Xiaoxue, Zhang, Ruijie, Liu, Chunxiao, Dong, Xiaoqing, Zhang, Shuangquan, Huang, Shile, Chen, Long
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600640/
https://ncbi.nlm.nih.gov/pubmed/28300280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25913
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