Gene loci associated with insulin secretion in islets from nondiabetic mice

Genetic susceptibility to type 2 diabetes is primarily due to β cell dysfunction. However, a genetic study to directly interrogate β cell function ex vivo has never been previously performed. We isolated 233,447 islets from 483 Diversity Outbred (DO) mice maintained on a Western-style diet, and meas...

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Detaylı Bibliyografya
Yayımlandı:J Clin Invest
Asıl Yazarlar: Keller, Mark P., Rabaglia, Mary E., Schueler, Kathryn L., Stapleton, Donnie S., Gatti, Daniel M., Vincent, Matthew, Mitok, Kelly A., Wang, Ziyue, Ishimura, Takanao, Simonett, Shane P., Emfinger, Christopher H., Das, Rahul, Beck, Tim, Kendziorski, Christina, Broman, Karl W., Yandell, Brian S., Churchill, Gary A., Attie, Alan D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763251/
https://ncbi.nlm.nih.gov/pubmed/31343992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129143
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