Gene loci associated with insulin secretion in islets from nondiabetic mice

Genetic susceptibility to type 2 diabetes is primarily due to β cell dysfunction. However, a genetic study to directly interrogate β cell function ex vivo has never been previously performed. We isolated 233,447 islets from 483 Diversity Outbred (DO) mice maintained on a Western-style diet, and meas...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Keller, Mark P., Rabaglia, Mary E., Schueler, Kathryn L., Stapleton, Donnie S., Gatti, Daniel M., Vincent, Matthew, Mitok, Kelly A., Wang, Ziyue, Ishimura, Takanao, Simonett, Shane P., Emfinger, Christopher H., Das, Rahul, Beck, Tim, Kendziorski, Christina, Broman, Karl W., Yandell, Brian S., Churchill, Gary A., Attie, Alan D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2019
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763251/
https://ncbi.nlm.nih.gov/pubmed/31343992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129143
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