Pleiotropic impact of DNA-PK in cancer and implications for therapeutic strategies

PURPOSE: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types, and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive...

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Publicado no:Clin Cancer Res
Main Authors: Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F., Raymon, Heather K., McCue, Peter A., Shafi, Ayesha A., Leiby, Benjamin E., de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J., Mandigo, Amy C., Chand, Saswati N., Schiewer, Matthew J., Brand, Lucas J., Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S., Gomella, Leonard G., Lallas, Costas D., Trabulsi, Edouard J., Feng, Felix Y., Filvaroff, Ellen H., Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744985/
https://ncbi.nlm.nih.gov/pubmed/31266833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2207
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