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USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair

Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activation and modification of target substrates to promote pro-oncogenic phenotypes. Here, in vivo characterization of tumor-associated USP22 upregulation and unbiased interrogation of USP22-regulated functions in vitro...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: McCann, Jennifer J., Vasilevskaya, Irina A., Neupane, Neermala Poudel, Shafi, Ayesha A., McNair, Christopher, Dylgjeri, Emanuela, Mandigo, Amy C., Schiewer, Matthew J., Schrecengost, Randy S., Gallagher, Peter, Stanek, Timothy J., McMahon, Steven B., Berman-Booty, Lisa D., Ostrander, William F., Knudsen, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814394/
https://ncbi.nlm.nih.gov/pubmed/31740444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1033
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