USP22 functions as an oncogenic driver in prostate cancer by regulating cell proliferation and DNA repair

Emerging evidence indicates the deubiquitinase USP22 regulates transcriptional activation and modification of target substrates to promote pro-oncogenic phenotypes. Here, in vivo characterization of tumor-associated USP22 upregulation and unbiased interrogation of USP22-regulated functions in vitro...

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Pubblicato in:Cancer Res
Autori principali: McCann, Jennifer J., Vasilevskaya, Irina A., Neupane, Neermala Poudel, Shafi, Ayesha A., McNair, Christopher, Dylgjeri, Emanuela, Mandigo, Amy C., Schiewer, Matthew J., Schrecengost, Randy S., Gallagher, Peter, Stanek, Timothy J., McMahon, Steven B., Berman-Booty, Lisa D., Ostrander, William F., Knudsen, Karen E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7814394/
https://ncbi.nlm.nih.gov/pubmed/31740444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1033
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