The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

Mechanisms regulating DNA repair processes remain incompletely defined. Here, the circadian factor CRY1, an evolutionally conserved transcriptional coregulator, is identified as a tumor specific regulator of DNA repair. Key findings demonstrate that CRY1 expression is androgen-responsive and associa...

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Publicado no:Nat Commun
Main Authors: Shafi, Ayesha A., McNair, Chris M., McCann, Jennifer J., Alshalalfa, Mohammed, Shostak, Anton, Severson, Tesa M., Zhu, Yanyun, Bergman, Andre, Gordon, Nicolas, Mandigo, Amy C., Chand, Saswati N., Gallagher, Peter, Dylgjeri, Emanuela, Laufer, Talya S., Vasilevskaya, Irina A., Schiewer, Matthew J., Brunner, Michael, Feng, Felix Y., Zwart, Wilbert, Knudsen, Karen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7810852/
https://ncbi.nlm.nih.gov/pubmed/33452241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20513-5
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