CRYPTOCHROMES confer robustness, not rhythmicity, to circadian timekeeping

Circadian rhythms are a pervasive property of mammalian cells, tissues and behaviour, ensuring physiological adaptation to solar time. Models of cellular timekeeping revolve around transcriptional feedback repression, whereby CLOCK and BMAL1 activate the expression of PERIOD (PER) and CRYPTOCHROME (...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Putker, Marrit, Wong, David C S, Seinkmane, Estere, Rzechorzek, Nina M, Zeng, Aiwei, Hoyle, Nathaniel P, Chesham, Johanna E, Edwards, Mathew D, Feeney, Kevin A, Fischer, Robin, Peschel, Nicolai, Chen, Ko‐Fan, Vanden Oever, Michael, Edgar, Rachel S, Selby, Christopher P, Sancar, Aziz, O’Neill, John S
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8013833/
https://ncbi.nlm.nih.gov/pubmed/33491228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106745
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