USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression

Increasing evidence links deregulation of the USP22 deubitiquitylase to cancer development and progression in a select group of tumor types, but its specificity and underlying mechanisms of action are not well-defined. Here we show that USP22 is a critical promoter of lethal tumor phenotypes that ac...

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Autori principali: Schrecengost, Randy S, Dean, Jeffry L, Goodwin, Jonathan F, Schiewer, Matthew J, Urban, Mark W, Stanek, Timothy J, Sussman, Robyn T, Hicks, Jessica L, Birbe, Ruth C, Draganova-Tacheva, Rossitza A, Visakorpi, Tapio, DeMarzo, Angelo M, McMahon, Steven B, Knudsen, Karen E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947329/
https://ncbi.nlm.nih.gov/pubmed/24197134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-1954
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