The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2)

Pluripotent embryonic stem cells (ESCs) undergo self-renewal until stimulated to differentiate along specific lineage pathways. Many of the transcriptional networks that drive reprogramming of a self-renewing ESC to a differentiating cell have been identified. However, fundamental questions remain u...

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Detalhes bibliográficos
Main Authors: Sussman, Robyn T., Stanek, Timothy J., Esteso, Paul, Gearhart, John D., Knudsen, Karen E., McMahon, Steven B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745368/
https://ncbi.nlm.nih.gov/pubmed/23760504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.469783
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