Pleiotropic impact of DNA-PK in cancer and implications for therapeutic strategies

PURPOSE: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types, and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive...

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Xehetasun bibliografikoak
Argitaratua izan da:Clin Cancer Res
Egile Nagusiak: Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F., Raymon, Heather K., McCue, Peter A., Shafi, Ayesha A., Leiby, Benjamin E., de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J., Mandigo, Amy C., Chand, Saswati N., Schiewer, Matthew J., Brand, Lucas J., Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S., Gomella, Leonard G., Lallas, Costas D., Trabulsi, Edouard J., Feng, Felix Y., Filvaroff, Ellen H., Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744985/
https://ncbi.nlm.nih.gov/pubmed/31266833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2207
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