Pleiotropic impact of DNA-PK in cancer and implications for therapeutic strategies

PURPOSE: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types, and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive...

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Gepubliceerd in:Clin Cancer Res
Hoofdauteurs: Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F., Raymon, Heather K., McCue, Peter A., Shafi, Ayesha A., Leiby, Benjamin E., de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J., Mandigo, Amy C., Chand, Saswati N., Schiewer, Matthew J., Brand, Lucas J., Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S., Gomella, Leonard G., Lallas, Costas D., Trabulsi, Edouard J., Feng, Felix Y., Filvaroff, Ellen H., Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744985/
https://ncbi.nlm.nih.gov/pubmed/31266833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2207
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