Pleiotropic impact of DNA-PK in cancer and implications for therapeutic strategies

PURPOSE: DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types, and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Dylgjeri, Emanuela, McNair, Christopher, Goodwin, Jonathan F., Raymon, Heather K., McCue, Peter A., Shafi, Ayesha A., Leiby, Benjamin E., de Leeuw, Renée, Kothari, Vishal, McCann, Jennifer J., Mandigo, Amy C., Chand, Saswati N., Schiewer, Matthew J., Brand, Lucas J., Vasilevskaya, Irina, Gordon, Nicolas, Laufer, Talya S., Gomella, Leonard G., Lallas, Costas D., Trabulsi, Edouard J., Feng, Felix Y., Filvaroff, Ellen H., Hege, Kristin, Rathkopf, Dana, Knudsen, Karen E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744985/
https://ncbi.nlm.nih.gov/pubmed/31266833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-2207
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