Positive selection in dNTPase SAMHD1 throughout mammalian evolution

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Monit, Christopher, Morris, Elizabeth R., Ruis, Christopher, Szafran, Bart, Thiltgen, Grant, Tsai, Ming-Han Chloe, Mitchison, N. Avrion, Bishop, Kate N., Stoye, Jonathan P., Taylor, Ian A., Fassati, Ariberto, Goldstein, Richard A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://ncbi.nlm.nih.gov/pubmed/31451672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908755116
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