Positive selection in dNTPase SAMHD1 throughout mammalian evolution

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Monit, Christopher, Morris, Elizabeth R., Ruis, Christopher, Szafran, Bart, Thiltgen, Grant, Tsai, Ming-Han Chloe, Mitchison, N. Avrion, Bishop, Kate N., Stoye, Jonathan P., Taylor, Ian A., Fassati, Ariberto, Goldstein, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://ncbi.nlm.nih.gov/pubmed/31451672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908755116
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados