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Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization
[Image: see text] SAMHD1 is a GTP-activated nonspecific dNTP triphosphohydrolase that depletes dNTP pools in resting CD4+ T cells and macrophages and effectively restricts infection by HIV-1. We have designed a nonsubstrate dUTP analogue with a methylene bridge connecting the α phosphate and 5′ carb...
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| Main Authors: | , , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Chemical
Society
2014
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4105058/ https://ncbi.nlm.nih.gov/pubmed/24983818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja5035717 |
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