Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity

по Bumpus, Namandjé N., Hollenberg, Paul F.
Опубликовано 2008

Cross-Linking of Human Cytochrome P450 2B6 to NADPH-Cytochrome P450 reductase: Identification of a Potential Site of Interaction

по Bumpus, Namandjé N., Hollenberg, Paul F.
Опубликовано 2010

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-Stimulated Hepatic Expression of Cyp4a10, Cyp4a14, Cyp4a31, and Other Peroxisome Proliferator-Activated Receptor α-Responsive...

по Bumpus, Namandjé N., Johnson, Eric F.
Опубликовано 2011

Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabol...

по Yanakakis, Lindsay J., Bumpus, Namandjé N.
Опубликовано 2012

Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice

по Avery, Lindsay B., Bumpus, Namandjé N.
Опубликовано 2014

A Targeted Proteomics Approach for Profiling Murine Cytochrome P450 Expression

по Hersman, Elisabeth M., Bumpus, Namandjé N.
Опубликовано 2014

Structure–Activity Studies Reveal the Oxazinone Ring Is a Determinant of Cytochrome P450 2B6 Activity Toward Efavirenz

по Cox, Philip M., Bumpus, Namandjé N.
Опубликовано 2014

Single heteroatom substitutions in the efavirenz oxazinone ring impact metabolism by CYP2B6

по Cox, Philip M., Bumpus, Namandjé N.
Опубликовано в: ChemMedChem (2016)

Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc

по Lu, Yanhui, Hendrix, Craig W., Bumpus, Namandjé N.
Опубликовано 2012

Dissimilarities in the Metabolism of Antiretroviral Drugs used in HIV Pre-exposure Prophylaxis in Colon and Vagina Tissues

по To, Elaine E., Hendrix, Craig W., Bumpus, Namandjé N.
Опубликовано 2013

Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

по Seamon, Kyle J., Bumpus, Namandjé N., Stivers, James T.
Опубликовано в: Biochemistry (2016)

Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir

по Hamlin, Allyson N, Tillotson, Joseph, Bumpus, Namandjé N
Опубликовано в: Pharmacogenomics (2019)

Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

по Lade, Julie M., Avery, Lindsay B., Bumpus, Namandjé N.
Опубликовано 2013

Efavirenz and Efavirenz-like Compounds Activate Human, Murine, and Macaque Hepatic IRE1α-XBP1

по Heck, Carley J. S., Hamlin, Allyson N., Bumpus, Namandjé N.
Опубликовано в: Mol Pharmacol (2019)

Pharmacogenomics of Antiretroviral Drug Metabolism and Transport

по Yu, Zaikuan J., Mosher, Eric P., Bumpus, Namandjé N.
Опубликовано в: Annu Rev Pharmacol Toxicol (2020)

Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death

по Heck, Carley J. S., Seneviratne, Herana Kamal, Bumpus, Namandjé N.
Опубликовано в: J Med Chem (2020)

CYP3A5 Genotype Impacts Maraviroc Concentrations in Healthy Volunteers

по Lu, Yanhui, Fuchs, Edward J., Hendrix, Craig W., Bumpus, Namandjé N.
Опубликовано 2014

Response to “Clinical Relevance of CYP3A5 Genotype on Maraviroc Exposures”

по Lu, Yanhui, Fuchs, Edward J., Hendrix, Craig W., Bumpus, Namandjé N.
Опубликовано в: Drug Metab Dispos (2015)

Discovery of Genetic Variants of the Kinases That Activate Tenofovir in a Compartment-specific Manner

по Lade, Julie M., To, Elaine E., Hendrix, Craig W., Bumpus, Namandjé N.
Опубликовано в: EBioMedicine (2015)

MALDI Mass Spectrometry Imaging Reveals Heterogeneous Distribution of Tenofovir and Tenofovir Diphosphate in Colorectal Tissue of Subjects Receiving a Tenofovir-Containing Enema

по Seneviratne, Herana Kamal, Hendrix, Craig W., Fuchs, Edward J., Bumpus, Namandjé N.
Опубликовано в: J Pharmacol Exp Ther (2018)