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Biotransformation of the Antiretroviral Drug Etravirine: Metabolite Identification, Reaction Phenotyping, and Characterization of Autoinduction of Cytochrome P450-Dependent Metabolism

Etravirine (ETR) is a second-generation non-nucleoside reverse transcriptase inhibitor prescribed for the treatment of HIV-1. By using human liver microsomes (HLMs), cDNA-expressed cytochromes P450 (P450s), and UDP-glucuronosyltransferases (UGTs), the routes of ETR metabolism were defined. Incubatio...

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Bibliografski detalji
Glavni autori: Yanakakis, Lindsay J., Bumpus, Namandjé N.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310427/
https://ncbi.nlm.nih.gov/pubmed/22269145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.044404
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