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Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison

Rilpivirine is a nonnucleoside reverse transcriptase inhibitor used to treat HIV-1. In the present study, the pathways responsible for the biotransformation of rilpivirine were defined. Using human liver microsomes, the formation of two mono- and two dioxygenated metabolites were detected via ultra...

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Detaylı Bibliyografya
Asıl Yazarlar: Lade, Julie M., Avery, Lindsay B., Bumpus, Namandjé N.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811466/
https://ncbi.nlm.nih.gov/pubmed/23917319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01401-13
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