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Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity
Human P450 2B6 is a polymorphic enzyme involved in the oxidative metabolism of a number of clinically relevant substrates. The lysine 262 to arginine mutant of P450 2B6 (P450 2B6.4) has been shown to have differential effects on P450 2B6 catalytic activity. We previously reported that the mutant enz...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574649/ https://ncbi.nlm.nih.gov/pubmed/18621926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.048637 |
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