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New insights into the catalytic mechanism of vitamin K epoxide reductase (VKORC1) – The catalytic properties of the major mutations of rVKORC1 explain the biological cost associated to mutations()

The systematic use of antivitamin K anticoagulants (AVK) as rodenticides caused the selection of rats resistant to AVKs. The resistance is mainly associated to genetic polymorphisms in the Vkorc1 gene encoding the VKORC1 enzyme responsible for the reduction of vitamin K 2,3-epoxide to vitamin K. Fiv...

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Dettagli Bibliografici
Autori principali: Matagrin, Benjamin, Hodroge, Ahmed, Montagut-Romans, Adrien, Andru, Julie, Fourel, Isabelle, Besse, Stéphane, Benoit, Etienne, Lattard, Virginie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668507/
https://ncbi.nlm.nih.gov/pubmed/23772386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2013.02.001
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