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Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer

Sterile Alpha Motif and HD Domain Protein 1 (SAMHD1) is a unique enzyme that has important roles in nucleic acid metabolism, viral restriction, and the pathogenesis of autoimmune diseases and cancer. Although much attention has been focused on its dNTP triphosphohydrolase activity in viral restricti...

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Bibliografiske detaljer
Udgivet i:Biochemistry
Main Authors: Seamon, Kyle J., Bumpus, Namandjé N., Stivers, James T.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531264/
https://ncbi.nlm.nih.gov/pubmed/27775344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00986
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