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SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

The HIV-1 restriction factor SAMHD1 is a tetrameric enzyme activated by guanine nucleotides with dNTP triphosphate hydrolase activity (dNTPase). In addition to this established activity, there have been a series of conflicting reports as to whether the enzyme also possesses single-stranded DNA and/o...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Seamon, Kyle J., Sun, Zhiqiang, Shlyakhtenko, Luda S., Lyubchenko, Yuri L., Stivers, James T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513882/
https://ncbi.nlm.nih.gov/pubmed/26101257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv633
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