Positive selection in dNTPase SAMHD1 throughout mammalian evolution

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Monit, Christopher, Morris, Elizabeth R., Ruis, Christopher, Szafran, Bart, Thiltgen, Grant, Tsai, Ming-Han Chloe, Mitchison, N. Avrion, Bishop, Kate N., Stoye, Jonathan P., Taylor, Ian A., Fassati, Ariberto, Goldstein, Richard A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2019
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://ncbi.nlm.nih.gov/pubmed/31451672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908755116
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