Positive selection in dNTPase SAMHD1 throughout mammalian evolution

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Monit, Christopher, Morris, Elizabeth R., Ruis, Christopher, Szafran, Bart, Thiltgen, Grant, Tsai, Ming-Han Chloe, Mitchison, N. Avrion, Bishop, Kate N., Stoye, Jonathan P., Taylor, Ian A., Fassati, Ariberto, Goldstein, Richard A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2019
Aiheet:
PNAS Plus
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://ncbi.nlm.nih.gov/pubmed/31451672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908755116
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