Positive selection in dNTPase SAMHD1 throughout mammalian evolution

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Monit, Christopher, Morris, Elizabeth R., Ruis, Christopher, Szafran, Bart, Thiltgen, Grant, Tsai, Ming-Han Chloe, Mitchison, N. Avrion, Bishop, Kate N., Stoye, Jonathan P., Taylor, Ian A., Fassati, Ariberto, Goldstein, Richard A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744909/
https://ncbi.nlm.nih.gov/pubmed/31451672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908755116
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