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Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice

Cerebral amyloid angiopathy (CAA) is a common cause of brain hemorrhage in the elderly. It is found in the majority of patients with Alzheimer's disease (AD). The most common form of CAA is characterized by the deposition of the amyloid-β (Aβ) peptide in the walls of cerebral vessels, and this...

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Pubblicato in:J Neurosci
Autori principali: Fryer, John D., Taylor, Jennie W., DeMattos, Ronald B., Bales, Kelly R., Paul, Steven M., Parsadanian, Maia, Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2003
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740607/
https://ncbi.nlm.nih.gov/pubmed/12944519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-21-07889.2003
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