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Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice

Cerebral amyloid angiopathy (CAA) is a common cause of brain hemorrhage in the elderly. It is found in the majority of patients with Alzheimer's disease (AD). The most common form of CAA is characterized by the deposition of the amyloid-β (Aβ) peptide in the walls of cerebral vessels, and this...

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Publicat a:J Neurosci
Autors principals: Fryer, John D., Taylor, Jennie W., DeMattos, Ronald B., Bales, Kelly R., Paul, Steven M., Parsadanian, Maia, Holtzman, David M.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740607/
https://ncbi.nlm.nih.gov/pubmed/12944519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-21-07889.2003
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