Cargando...
Structural Basis for Diltiazem Block of a Voltage-Gated Ca(2+) Channel
Diltiazem is a widely prescribed Ca(2+) antagonist drug for cardiac arrhythmia, hypertension, and angina pectoris. Using the ancestral Ca(V) channel construct Ca(V)Ab as a molecular model for X-ray crystallographic analysis, we show here that diltiazem targets the central cavity of the voltage-gated...
Gardado en:
| Publicado en: | Mol Pharmacol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The American Society for Pharmacology and Experimental Therapeutics
2019
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6738535/ https://ncbi.nlm.nih.gov/pubmed/31391290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117531 |
| Tags: |
Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|