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Resting State Structure and Gating Mechanism of a Voltage-gated Sodium Channel

Voltage-gated sodium (Na(V)) channels initiate action potentials in nerve, muscle, and other electrically excitable cells. The structural basis of voltage gating is uncertain because the resting state exists only at deeply negative membrane potentials. To stabilize the resting conformation, we inser...

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Publicat a:Cell
Autors principals: Wisedchaisri, Goragot, Tonggu, Lige, McCord, Eedann, Gamal El-Din, Tamer M., Wang, Liguo, Zheng, Ning, Catterall, William A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688928/
https://ncbi.nlm.nih.gov/pubmed/31353218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.031
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