Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin

Voltage-gated sodium (Na(V)) channels initiate action potentials in excitable cells, and their function is altered by potent gating-modifier toxins. The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac Na(V)1.5 channels with IC(50) = 11.4 nM. Here we reveal the str...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Jiang, Daohua, Tonggu, Lige, Gamal El-Din, Tamer M., Banh, Richard, Pomès, Régis, Zheng, Ning, Catterall, William A.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7782738/
https://ncbi.nlm.nih.gov/pubmed/33397917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20078-3
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