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Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin
Voltage-gated sodium (Na(V)) channels initiate action potentials in excitable cells, and their function is altered by potent gating-modifier toxins. The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac Na(V)1.5 channels with IC(50) = 11.4 nM. Here we reveal the str...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7782738/ https://ncbi.nlm.nih.gov/pubmed/33397917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20078-3 |
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