Structural basis for Ca(2+) selectivity of a voltage-gated calcium channel

Voltage-gated calcium (Ca(V)) channels catalyze rapid, highly selective influx of Ca(2+) into cells despite 70-fold higher extracellular concentration of Na(+). How Ca(V) channels solve this fundamental biophysical problem remains unclear. Here we report physiological and crystallographic analyses o...

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Hauptverfasser: Tang, Lin, Gamal El-Din, Tamer M., Payandeh, Jian, Martinez, Gilbert Q., Heard, Teresa M., Scheuer, Todd, Zheng, Ning, Catterall, William A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877713/
https://ncbi.nlm.nih.gov/pubmed/24270805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12775
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